7th Meeting of the EASD Study Group on the Genetics of Diabetes [EASD-SGGD]
7th Meeting of the EASD Study Group on the Genetics of Diabetes [EASD-SGGD]

EASD-SGGD Meeting in Prague 2019

The programme is subject to change.

Thursday May 16

 

12.00 – 13.30 Lunch in the poster area
13.30 – 13.45 Welcome and opening
   Jan Lebl, Štěpánka Průhová, Emma Ahlqvist

13.45 – 15.15 Session 1
  Genetics of Type 1 diabetes
  Chairs: Kateřina Kaňková, Sarah Flanagan
13.45 – 14.15 Flemming Pociot (Copenhagen, Denmark) - Genetics of beta-cell dysfunction during T1D development
14.15 – 14.45 Per H Groop (Helsinki, Finland) - The Genetic Landscape of Renal Complications in Type 1 Diabetes
14.45 – 15.15  Matthew Johnson (Exeter, UK) - Monogenic forms of autoimmune diabetes; challenges and opportunities

 

15.15 – 16.15 Poster session 1
  Posters 1-9 (T1D, MODY) Chairs: Ondřej Cinek, Zdeněk Šumník
  Posters 20-28 (T2D, Metabolism) Chairs: Ines Barroso, Jan Lebl
  Coffee/ Tea Break

 

16.15 – 18.15 Session 2
  Personalized medicine form a genetic perspective
  Chairs: Timothy Frayling, Christine Bellanne-Chantelot
16.15 – 16.45 Torben Hansen (Copenhagen, Denmark) - Genetics of metabolic traits: Lessons from isolated populations
16.45 – 17.15 Ewan Pearson (Dundee, UK) - Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery
  Oral Presentations : Animal models of diabetes
17.15 – 17.30 OP01 Lucie Šedová (Prague, Czech Republic) – Effects of NME7 CRISPR/CAS9-Targeting on metabolic syndrome-related parameters of Sprague Dawley rats
17.30 - 17.45 OP02 Eugenia Mazzaferro (Uppsala, Sweden) – Zebrafish as a model system to characterise causal genes for LDL cholesterol levels and downstream effects on atherosclerosis and diabetes risk
17.45 – 18.00 OP03 Marcel den Hoed (Uppsala, Sweden) – Zebrafish as a model system for systematic IMAGE- and CRISPR-CAS9-Based screens in insulin resistance
18.00 – 18.15 OP04 Natalie van Zuydam (Uppsala, Sweden) – A Zebrafish model for identifying putatively causal genes from diabetes associated loci
   

 

19.30 Dinner (restaurant Profesni Dum)

 

Friday May 17

 

9.00 – 11.00 Session 3
  Monogenic diabetes
  Chairs: Leen M´t Hart, Daniela Gasperníková
9.00 – 9.30 Andrew Hattersley (Exeter, UK) - New genes and new insights in monogenic diabetes
9.30  – 10.00 Lise Bjørkhaug Gundersen (Bergen, Norway) - Significance of functional studies of HNF-coding gene variants for diabetes classification
  Oral Presentations: MODY
10.00 – 10.15 OP05 Jarno Kettunen (Helsinki, Finland) – The family-based assessment of HNF1A-MODY
10.15 - 10.30 OP06 Kevin Colclough (Exeter, UK) – Next generation sequencing for monogenic diabetes increases diagnostic yield and identifies patients that would not be diagnosed by single gene testing according to clinical phenotype
10.30 – 10.45 OP07 Alexander Sidelmann Christensen (Copenhagen, Denmark) – Both GIP and GLP-1 potentiate Sulfonylurea-induced insulin secretion in patients with HNF1A-diabetes
10.45 – 11.00 OP08 Elisa De Franco (Exeter, UK) – De novo variants in EIF2B1 are a novel cause of permanent neonatal diabetes and transient liver dysfunction
   

 

11.00 – 11.30 Coffee/ Tea Break

 

  Oral Presentations: Monogenic beta-cell disorders
  Chairs: Niels Grarup, Katarine Owen
11.30 – 11.45 OP09 Jayne Houghton (Exeter, UK) – Routine screening of the KDM6A and KMT2D genes in individuals with hyperinsulinism allows for an earlier diagnosis of Kabuki screening
11.45 – 12.00 OP10 Thomas Laver (Exeter, UK) – Large deletions are an underappreciated cause of hyperinsulinism
12.00 – 12.15 OP11 Cécile Saint-Martin (Paris, France) – NGS analysis of monogenic diabetes patients showed that maternally inherited diabetes and deafness is underdiagnosed
12.15 – 12.30 OP12 Marcus Tuke (Exeter, UK) – Assessing the pathogenicity and penetrance of HNF1B deletions and duplications in UK Biobank
12.30 – 12.45 OP13 Ingrida Stankute (Kaunas, Lithuania) – High incidence of monogenic diabetes in Lithuanian pediatric and young adult diabetes patients
12.45 - 13.00 OP14 Kashyap Patel (Exeter, UK) – Different genetic testing strategies for monogenic diabetes are needed in populations with higher rates of consanguinity
   

 

13.00 – 14.30 Lunch in the poster area
13.20 – 14.20 Poster session 2
  Posters 10-19 (MODY) Chairs: Kevin Colcluough, Julie støy
  Posters 29-39 (Obesity) Chairs: Ruth Loos, Roderick C.Slieker

 

14.30 – 16.30 Session 4
  Different subgroups in Diabetes
  Chairs: Antonio Luis Cuesta-Muños, Martine Vaxillaire
14.30 – 15.00 Emma Ahlqvist (Malmö, Sweden) – Clinical and genetic subtypes of diabetes
15.00 – 15.30 Amelie Bonnefond (Lille, France) - Towards the genetic continuum between common type 2 diabetes and monogenic diabetes
  Oral Presentations: Different subgroups of diabetes – practical implications
15.30 – 15.45 OP15 Michael Weedon (Exeter, UK) – Using UK Biobank to assess the pathogenicity, penetrance and expressivity of monogenic diabetes variants
15.45 – 16.00 OP16 Matthew Wakeling (Exeter, UK) – Homozygosity mapping from small targeted NGS panel using Savvy homozygosity – getting more from less
16.00 – 16.15 OP17 Adem Dawed (Dundee, UK) – Loss of function variants in the CYP2C9 & SLCO1B1 are associated with improved glycaemic response to sulphonylureas: A GoDARTS Study
16.15 - 16.30 OP18 James W Harrison (Exeter, UK) – A Type 1 Diabetes Genetic Risk Score improves classification of diabetes in India
   

 

16.30 – 17.00 Coffee/ Tea Break

 

17.00 – 18.00 Session 5
  Microbioma in Type 1 and Type 2 diabetes
  Chairs: Zdeněk Šumník, Torben Hansen
17.00 – 17.30 Ondřej Cinek (Prague, Czech Republic) - Microbiota components and the development of type 1 diabetes - bacteria, viruses, and beyond
17.30 – 18.00 Oluf Pedersen (Copenhagen, Denmark) - The intestinal microbiota and human metabolism

 

19.30 Dinner (restaurant Mlynec)

 

Saturday May 18

 

9.00 – 11.00 Session 6
  Metabolism and Obesity I. (OMICS)
  Chairs: Michael Weedon, Phillipe Froguel
9.00 – 9.30 Roderick C Slieker (Leiden, the Netherlands) - A multi-omics approach towards type 2 diabetes
9.30 – 10.00 Jan-Wilhelm Kornfeld (Köln, Germany; Odense, Denmark) - Regulation of metabolism by long noncoding RNAs
  Oral Presentations: Epigenetics and gene expression
10.00 – 10.15 OP19 Pradeep Bompara (Malmö, Sweden) – Epigenetic and transcriptome landscapes of glucose-induced histone acetylation in pancreatic islets
10.15 – 10.30 OP20 Ji Chen (Cambridge, UK) – Leveraging ancestry differences for glycaemic trait locus discovery and fine-mapping
10.30 – 10.45 OP21 Jason Torres (Oxford, UK) – Integration of epigenetic maps and High-Resolution Chromatin Interactions implicates effector transcripts at loci associated with Type 2 diabetes in human pancreatic EndoC- β H1 cells
10.45 – 11.00 OP22 Jun Liu (Rotterdam, the Netherlands) – Novel CPG sites of glucose and insulin homeostasis: An integrative Cross-Omics Analysis
   
 

 

11.00 – 11.30 Coffee/ Tea Break

 

11.30 – 13.00 Session 7
  Metabolism and Obesity II.
  Chairs: Lenka Petruželková, Jan-Willhelm Kornfeld
  Oral Presentations: Population studies
11.30 – 11.45 OP23 Jessica Tyrrell (Exeter, UK) – Comparing the causal effects of diabetes-related traits on measures of micro-and macro-vascular disease
11.45 – 12.00 OP24 Zhanna Balkhiyarova (London, UK) – Common genetic loci associated with Type 2 diabetes mellitus, depressive symptoms and anxiety
12.00 – 12.15 OP25 Sadia Saeed (Lille, France) – Augmented exome sequencing (CoDE-Seg) identifies point mutations and copy number variants causing extreme obesity in 48% of patients from a consanguineous Pakistani population
12.15 – 12.30 OP26 Marika Kaakinen (London, UK) – Multiple epigenetic and metabolomic markers predict glycaemic health in middle-aged men and woman
 
  Genetics of obesity
12.30 – 13.00 Ruth Loos (New York, USA) -  Genes that make you fat, but keep you healthy
13.00 – 13.30 Best poster and oral presentation Award ceremony*
  Chairs: Štěpánkoa Průhová, Jan Lebl, Amelie Bonnefond
   
Best poster presentation award
Best oral presentation award
*Mandatory for winners to be present
Closing remarks

 

 

13.30 Lunch

 

LOOKING FORWARD TO

MEETING YOU IN PRAGUE
12
Months
9
Days
1
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